Chemical Catalog

Chemical Catalog & Custom Building Blocks

Astinova maintains a growing portfolio of advanced modality building blocks, intermediates, and custom synthesis standards available on request.

Publication-style plate of advanced modality building block molecules and linker motifs.
Publication-Style Molecule Plate
Full catalog available on request. Contact us to discuss specific compound needs.

Catalog Categories

Our catalog covers key compound classes for advanced modality drug discovery programs.

PROTAC Building Blocks

E3 Ligase Ligands

  • › VHL ligand (VH032 analog)
  • › Pomalidomide (CRBN)
  • › Lenalidomide derivatives
  • › Bestatin analogs (IAP)
Available on request

PEG Linkers

  • › PEG1–PEG12 diamine
  • › Boc-PEG-acid series
  • › NH2-PEG-NHS ester
  • › Azide-PEG-amine
Available on request

Alkyl & Mixed Linkers

  • › C2–C8 diamine linkers
  • › Piperazine linkers
  • › Piperidinyl linkers
  • › Mixed alkyl-PEG hybrids
Available on request

Reactive Handles

  • › NHS-ester activated acids
  • › Alkyne-bearing warheads
  • › Azide-functionalized components
  • › Amine-reactive probes
Available on request

ADC Components

Cleavable Linkers

  • › Val-Cit-PABC linkers
  • › Disulfide-based linkers
  • › Acid-labile hydrazide linkers
  • › β-glucuronide linkers
Available on request

Non-Cleavable Linkers

  • › Maleimide-caproyl linkers
  • › NHS-PEG4-maleimide
  • › Thioether stable linkers
  • › Bifunctional crosslinkers
Available on request

Payload Analogs

  • › Auristatin analogs (MMAE-type)
  • › Maytansinoid analogs (DM1-type)
  • › Calicheamicin analogs
  • › Novel cytotoxin intermediates
Custom synthesis

Conjugation Handles

  • › Thiol-reactive maleimides
  • › Amine-reactive NHS esters
  • › Aldehyde-reactive hydrazides
  • › Click chemistry handles
Available on request

Peptide Synthesis Reagents

Modified Amino Acids

  • › Fmoc-N-Me amino acids
  • › Fmoc-β-amino acids
  • › Hydroxy-proline derivatives
  • › D-amino acid building blocks
Available on request

Non-Natural Amino Acids

  • › α-methyl amino acids (Aib series)
  • › Azido/alkyne amino acids
  • › Unnatural side chain variants
  • › Conformationally constrained
Custom synthesis

Coupling Reagents

  • › HATU, HBTU, TBTU analogs
  • › Oxazolone-minimizing reagents
  • › Activated ester intermediates
  • › Mixed anhydride precursors
Custom synthesis

Phosphoramidites

  • › 2'-OMe RNA phosphoramidites
  • › 2'-F modified phosphoramidites
  • › LNA monomers
  • › PS backbone precursors
Custom synthesis

Chiral Building Blocks

Chiral Auxiliaries

  • › Oxazolidinone-based auxiliaries
  • › Evans auxiliary analogs
  • › Camphorsultam derivatives
  • › Sulfinyl chiral controllers
Available on request

Asymmetric Intermediates

  • › Enantiopure amino alcohols
  • › Chiral prolinol derivatives
  • › Asymmetric epoxide building blocks
  • › Enantiopure lactams
Custom synthesis

Atropisomeric Scaffolds

  • › Axially chiral biaryl compounds
  • › BINAP/BINOL analogs
  • › Atroposelective PROTAC scaffolds
  • › Resolved atropisomers
Custom synthesis

Macrocycle Precursors

  • › Chiral linear macrocycle precursors
  • › Pre-cyclization intermediates
  • › High-dilution cyclization substrates
  • › RCM diene precursors
Custom synthesis

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